This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Ask your doctor or pharmacist about using this product safely. You might also get the herb at your nearest supermarket/pharmacy. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. However, there is no solid evidence that supports these claims. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Some people also call it Mary thistle and holy thistle. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. Call your doctor for medical advice about side effects. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). An important part of taking supplements is proper storage. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. However, researchers theorize that it does. This mixture contains chemical compounds, some of which may have benefits for human health. However, more direct research is warranted in this regard. This product is not recommended for use during pregnancy. Take your next dose at the regular time. Does milk thistle cause any side effects? Milk thistle can also cause an allergic reaction in some people. Is the ketogenic diet right for autoimmune conditions? anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Cathy Wong is a nutritionist and wellness expert. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. This product may contain inactive ingredients, which can cause allergic reactions or other problems. It is native to Mediterranean countries. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. There are other supplements that work similarly to milk thistle. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Read our. Milk thistle is sold as an oral capsule, tablet and liquid extract. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. This article will explore the potential uses of milk thistle. Vegetable Oil: Nutrition Fac Olive Oil Vs. Possibly. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Talk to your pharmacist for more details. Over-indulging in this powerful herb may do you more harm than you know. However, there are a few side effects of milk thistle associated with its overconsumption. For this reason, it is important to buy milk thistle from reputable retailers. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. You can find milk thistle as loose-leaf tea or in tea bags. Effects of Silybum marianum (L.) Gaertn. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Dosage is also typically listed on the nutrition label of supplements. increased sweating. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Duplication is encouraged. 2007;2007(4):CD003620. Our team thoroughly researches and evaluates the recommendations we make on our site. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. All rights reserved. More study is needed to confirm this. 3 are moderate, and 1 is minor. Otherwise, call a poison control center right away. 1982;17:51721. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Call your doctor for medical advice about side effects. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. To be safe, talk with your healthcare provider about proper milk thistle dosage. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. No supplement is intended to treat, cure, or prevent disease. The terms "milk thistle" and "silymarin" are often used interchangeably. Silymarin is believed to have antioxidant properties. If you have any questions, ask your doctor or pharmacist. (2021). Cymbalta side effects (more detail) Rev Diabet Stud. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. National Center for Complementary and Integrative Health. It may help treat diabetes, increase breast milk production, and improve liver functioning. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. How long does it take for milk thistle to start working? It can be consumed in supplement form or as a tea. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Who should not take Milk Thistle Capsule? Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Consult your doctor before breast-feeding. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Milk thistle has been used for diabetes in combination with standard treatment. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. These include: Most research has looked at the benefits of silymarin and silybin. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. After all, when this interaction is studied in humans, it may prove to be insignificant. A double-blind controlled study. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Vegetable Oil: Nutrition Facts And Differences. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Email this report to a friend, doctor, or patient. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. 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